KSHV 2020 will mark the beginning of a new quarter century since the discovery of this cancer virus. The organizing committee and the participants felt that this should mark a new era in inclusiveness and global outreach such that the numerous groundbreaking discoveries about the virus can be more quickly translated to preventing the disease and treating the affected patients. This has provided a strong rationale to bringing the conference for the first time to Africa, for the developed countries researchers to engage African researchers, clinician and trainees, to foster collaborations in basic, translational and clinical research.